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This work was funded by the Fogarty International Center, National Institute of Diabetes and Digestive and Kidney Diseases, National institute on aging of the National Institutes of Health grants R01HL144941 (AK), 2D43TW009744 (SM), R21TW012635 (AK and SM), and the American Heart Association Award Number 24IVPHA1297559 (AK and SM)